The 15-year-old is stepping up from karting into single-seaters after a very successful karting career.
Tsolov won the WSK Open Cup – Mini in 2019 before finishing second in the WSK Final Cup – OK last year.
He is also an Alpine affiliated driver and part of Fernando Alonso‘s management company A14 Management.
Tsolov said: “I am really excited for the opportunity to work with Campos Racing because they are one of the best teams and their competencies are beyond F4 racing also in F3 and F2.
“Already pushing hard and I am going to give my best this season.”
The Campos Racing Team Principal Adrian Campos added: “It makes us special pleasure to add Nikola (Tsolov) to our driver line-up.
“First, because he is one of the most promising karting drivers of the newest generation and his future in single-seater racing is bright.
“I feel convinced we will be able to achieve success working together. And second, because he is a Fernando Alonso’s pupil and it means that Fernando is linked again to Campos Racing, which is a return to his former racing home.
“So, it gives us huge motivation. I have no doubts my father would have been extremely excited as well.”
Tsolov will be joined by some esteemed company at Campos in Filip Jeni?, Georg Kelstrup, and Australian talent Hugh Barter.
Spanish F4 will race at some world-class venues in 2022 such as the season opener at the Algarve International Circuit as the series shadows DTM.
Spa-Francorchamps will also be graced by Spanish F4 on the 8-9 of July before the final round of the campaign at the Circuit de Barcelona-Catalunya in Spain.
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* Image Credit: Formula Motorsport Limited